Have to agree with Fox...... What performance issues are you having with your system that your trying to correct? If you could be a bit specific we can help you out. Slow start up, slow load times, stability issue, consistently slow performance in games, what?
Buub, to say that your system shouldn't need to have its registry "cleaned" is to say that you shouldn't maintain your car until it stop working, preventive maintenance. I wouldn't recommend doing this every day, but once a week isnt horrible and at least once a month. Of course if you make MANY changes to your system its a good idea to do your maintenance afterwards.
As for CCleaner, I have used it for sometime, great program for cleaning up left over registries after uninstalling software/devices. I will warn for ATI users on Windows 7 though... if you have it checked to remove Installer files, it will remove your ATI video card installer files from C:/ATI... which on older systems isnt an issue. For some reason Windows 7 looks for some files in there on startup (regardless of everything being disabled in the MSConfig startup menu) and you will have an annoying pop-up. Unzipping the ATI drivers back into that folder does not solve the issue, nor does reinstalling CCC or the Drivers fix it, little issue that im sure a new version CCleaner will resolve. Other than that, NEVER had it remove a file that i needed or that it should have.
I can also vouch for PerfectDisk, its boot-time, MBR, and smart placement make it a step above your built in windows defrag utility, ive noticed a good little bit of a performance increase with smart placement on my Hitachi 5400 Laptop HDD.
Shining..... to say that HDD's belong in a museum is pretty bold as of yet. Sure in 4-5 years that will be the case, maybe not even then. Hard drives as they stand now provide you MASSIVE amounts of storage, something that a SSD cant do, and if it could it would cost you more than its worth. Its like saying that RAM belongs in a museum and you should just push CPU manufacturers to up L2 cache in place of RAM.... not effective, not possible (yet

) I also don't know why the heck your pushing Intel SDD, as though they are the only ones possible that could make a SDD, you almost sound like an Intel rep or saleman..... There are others who have a good reputation and are also going along the road to larger, faster and cheaper SSD. Corsair, Cruical, Patriot, OCZ, pretty much any major memory manufacturer. Whether they have the features that you will want in a SDD right now, like TRIM, that depends on how much your willing to spend, and thats likely to be a pretty penny when compared to its HDD brethren.
"But what ... is it good for?"
Engineer at the Advanced Computing Systems Division of IBM, 1968, commenting on the microchip.
"I think there is a world market for maybe five computers."
Thomas Watson, chairman of IBM, 1943